Dr. Bill Cortner has been performing experimental surgery on human guinea pigs without authorization and against the advice of his father| also a surgeon. WhenBill's fiancée Jan Compton is decapitated in an automobile accident| he manages to keep her brain alive. He now needs to find a new body for his bride-to-be andsettles on Doris Powell| a glamor model with a facial disfigurement. Jan meanwhile doesn't want to continue her body-less existence and calls upon the creaturehidden in the basement| one of Bill Cortner's unsuccessful experiments| to break loose.