After countless millennia of watching| waiting and stalking| the unholy creatures known as werewolves are poised to inherit the earth. After newswoman Karen White's shocking on-screen transformation and violent death| her brother Ben is approached by Stefan Crosscoe| a mysterious gentleman who claims that Karen has actually become a werewolf. But this is the least of their worries... To save mankind| Stefan and Ben must travel to Transylvania to battle and destroy Stirba| the immortal queen of all werewolves| before she is restored to her full powers!